Which agent is not effective in treating psoriasis?

Topical antifungals are not effective in treating psoriasis because they are specifically designed to combat fungal infections. Psoriasis is an autoimmune condition characterized by rapid skin cell turnover, leading to thick, scaly plaques. Treatment typically involves agents that specifically target the underlying inflammatory process or help to manage keratinocyte proliferation.

Topical corticosteroids are effective because they reduce inflammation and help to alleviate symptoms associated with psoriasis. Phototherapy works by exposing the skin to ultraviolet light, which can slow the growth of skin cells and reduce inflammation. Systemic medications, such as immunosuppressants or biologics, target the immune response involved in psoriasis at a broader level, making them effective in managing more severe cases.

Since topical antifungals do not address either the inflammation or the accelerated skin cell turnover inherent to psoriasis, they are ineffective for this particular condition.